SPN, Sam/Dean, PG-13
The story (and art) feature Stanford-era Winchesters, with sexy police intern Sam and fake-FBI Dean teaming up to hunt a murderous creature. (And nurse UST!)
Lurid posing, gratuitous shirtlessness, and geographically implausible background behind the cut.
Credit for the composition and the ludicrous stack of background elements goes to the Google Image search results for "romance novel cover", especially these two images.
The story, meanwhile, is hopefully still forthcoming!